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xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the intracellular synthesis of GSH, whereby xCT determines the intr...

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Detalhes bibliográficos
Publicado no:Oncol Lett
Main Authors: Sugiyama, Akiko, Ohta, Tsuyoshi, Obata, Miyuki, Takahashi, Kanako, Seino, Manabu, Nagase, Satoru
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400102/
https://ncbi.nlm.nih.gov/pubmed/32782585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.11813
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