xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma

Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the intracellular synthesis of GSH, whereby xCT determines the intr...

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Bibliografiske detaljer
Udgivet i:Oncol Lett
Main Authors: Sugiyama, Akiko, Ohta, Tsuyoshi, Obata, Miyuki, Takahashi, Kanako, Seino, Manabu, Nagase, Satoru
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400102/
https://ncbi.nlm.nih.gov/pubmed/32782585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2020.11813
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