GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway

BACKGROUND & AIMS: Transforming growth factor (TGF-β)–induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis and portal hypertension. GIPC (also referred to as synectin) is a downstream signal activation molecule...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Yaqoob, Usman, Luo, Fanghong, Greuter, Thomas, Jalan Sakrikar, Nidhi, Sehrawat, Tejasav S., Lu, Jianwen, Hu, Xiao, Gao, Jinhang, Kostallari, Enis, Chen, Jingbiao, Arab, Juan Pablo, Martin-Mateos, Rosa, Cao, Sheng, Shah, Vijay H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399184/
https://ncbi.nlm.nih.gov/pubmed/32447051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.05.005
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