Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation

Introduction: Many donor organs contain significant leukocyte reservoirs which upon transplantation activate recipient leukocytes to initiate acute rejection. We aimed to assess whether non-ischemic heart preservation via ex vivo perfusion promotes immunodepletion and alters the inflammatory status...

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Udgivet i:Front Immunol
Main Authors: Critchley, William R., Stone, John P., Liao, Qiuming, Qin, Guangqi, Risnes, Ivar, Trafford, Andrew, Scott, Helge, Sjöberg, Trygve, Steen, Stig, Fildes, James E.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399062/
https://ncbi.nlm.nih.gov/pubmed/32849549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01621
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