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N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to Control Inflammatory Demyelination

B cell depletion potently reduces episodes of inflammatory demyelination in multiple sclerosis (MS), predominantly through loss of innate rather than adaptive immunity. However, molecular mechanisms controlling innate versus adaptive B cell function are poorly understood. N-glycan branching, via int...

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Bibliografiske detaljer
Udgivet i:iScience
Main Authors: Mortales, Christie-Lynn, Lee, Sung-Uk, Manousadjian, Armen, Hayama, Ken L., Demetriou, Michael
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398982/
https://ncbi.nlm.nih.gov/pubmed/32745987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101380
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