Leveraging human genetics to identify safety signals prior to drug marketing approval and clinical use

INTRODUCTION: When a new drug or biologic product enters the market, its full spectrum of side effects is not yet fully understood, as use in the real world often uncovers nuances not suggested within the relatively narrow confines of preapproval preclinical and trial work. OBJECTIVE: We describe a...

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Detalhes bibliográficos
Publicado no:Drug Saf
Main Authors: Jerome, Rebecca N., Joly, Meghan Morrison, Kennedy, Nan, Shirey-Rice, Jana K., Roden, Dan M., Bernard, Gordon R., Holroyd, Kenneth J., Denny, Joshua C., Pulley, Jill M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398579/
https://ncbi.nlm.nih.gov/pubmed/32112228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-020-00915-6
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