Leveraging human genetics to identify safety signals prior to drug marketing approval and clinical use

INTRODUCTION: When a new drug or biologic product enters the market, its full spectrum of side effects is not yet fully understood, as use in the real world often uncovers nuances not suggested within the relatively narrow confines of preapproval preclinical and trial work. OBJECTIVE: We describe a...

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Udgivet i:Drug Saf
Main Authors: Jerome, Rebecca N., Joly, Meghan Morrison, Kennedy, Nan, Shirey-Rice, Jana K., Roden, Dan M., Bernard, Gordon R., Holroyd, Kenneth J., Denny, Joshua C., Pulley, Jill M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7398579/
https://ncbi.nlm.nih.gov/pubmed/32112228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40264-020-00915-6
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