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Combining endocannabinoids with retigabine for enhanced M-channel effect and improved K(V)7 subtype selectivity
Retigabine is unique among anticonvulsant drugs by targeting the neuronal M-channel, which is composed of K(V)7.2/K(V)7.3 and contributes to the negative neuronal resting membrane potential. Unfortunately, retigabine causes adverse effects, which limits its clinical use. Adverse effects may be reduc...
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| Udgivet i: | J Gen Physiol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7398146/ https://ncbi.nlm.nih.gov/pubmed/32365171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012576 |
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