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KCNE1 tunes the sensitivity of K(V)7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site
The voltage-gated potassium channel K(V)7.1 and the auxiliary subunit KCNE1 together form the cardiac I(Ks) channel, which is a proposed target for future anti-arrhythmic drugs. We previously showed that polyunsaturated fatty acids (PUFAs) activate K(V)7.1 via an electrostatic mechanism. The activat...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6080945/ https://ncbi.nlm.nih.gov/pubmed/30014849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37257 |
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