Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese

BACKGROUNDS: Cytochrome P450 (P450) 2E1 is one of the primary enzymes responsible for the metabolism of xenobiotics, such as drugs and environmental carcinogens. The genetic polymorphisms of the CYP2E1 gene in promoter and coding regions have been identified previously in the Han Chinese population...

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Udgivet i:PeerJ
Main Authors: Wang, Ting, Du, Huihui, Ma, Jingsong, Shen, Lu, Wei, Muyun, Zhao, Xianglong, Chen, Luan, Li, Mo, Li, Guorong, Xing, Qinghe, He, Lin, Qin, Shengying
Format: Artigo
Sprog:Inglês
Udgivet: PeerJ Inc. 2020
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397980/
https://ncbi.nlm.nih.gov/pubmed/32821545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.9628
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