XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells

Homologous recombination/end joining (HR/HEJ)-deficient cancers with BRCA mutations utilize alternative DNA double-strand break repair pathways, particularly alternative non-homologous end joining or microhomology-mediated end joining (alt-EJ/MMEJ) during S and G2 cell cycle phases. Depletion of alt...

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Detalhes bibliográficos
Publicado no:NAR Cancer
Main Authors: Eckelmann, Bradley J, Bacolla, Albino, Wang, Haibo, Ye, Zu, Guerrero, Erika N, Jiang, Wei, El-Zein, Randa, Hegde, Muralidhar L, Tomkinson, Alan E, Tainer, John A, Mitra, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
DNA Damage Sensing and Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397735/
https://ncbi.nlm.nih.gov/pubmed/32776008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa013
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