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A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis

Invasive strains of Streptococcus pyogenes with significantly reduced susceptibility to β-lactam antibiotics have been recently described. These reports have caused considerable concern in the international infectious disease, medical microbiology, and public health communities because S. pyogenes h...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Olsen, Randall J., Zhu, Luchang, Musser, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397459/
https://ncbi.nlm.nih.gov/pubmed/32407732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2020.04.014
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