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Second-Generation Pharmacological Chaperones: Beyond Inhibitors
Protein misfolding induced by missense mutations is the source of hundreds of conformational diseases. The cell quality control may eliminate nascent misfolded proteins, such as enzymes, and a pathological loss-of-function may result from their early degradation. Since the proof of concept in the 20...
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| Publicado no: | Molecules |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7397201/ https://ncbi.nlm.nih.gov/pubmed/32660097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25143145 |
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