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The GTPase-activating protein p120RasGAP has an evolutionarily conserved “FLVR-unique” SH2 domain

The Src homology 2 (SH2) domain has a highly conserved architecture that recognizes linear phosphotyrosine motifs and is present in a wide range of signaling pathways across different evolutionary taxa. A hallmark of SH2 domains is the arginine residue in the conserved FLVR motif that forms a direct...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jaber Chehayeb, Rachel, Wang, Jessica, Stiegler, Amy L., Boggon, Titus J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7397115/
https://ncbi.nlm.nih.gov/pubmed/32540970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013976
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