Stabilization of HIF-1α in Human Retinal Endothelial Cells Modulates Expression of miRNAs and Proangiogenic Growth Factors

Retinal hypoxia is one of the causative factors of diabetic retinopathy and is also one of the triggers of VEGF release. We hypothesized that specific dysregulated miRNAs in diabetic retinopathy could be linked to hypoxia-induced damage in human retinal endothelial cells (HRECs). We investigated in...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Lazzara, Francesca, Trotta, Maria Consiglia, Platania, Chiara Bianca Maria, D’Amico, Michele, Petrillo, Francesco, Galdiero, Marilena, Gesualdo, Carlo, Rossi, Settimio, Drago, Filippo, Bucolo, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396674/
https://ncbi.nlm.nih.gov/pubmed/32848728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01063
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