PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [(18)F]PF-06684511

PURPOSE: Beta-secretase 1 (BACE1) enzyme is implicated in the pathophysiology of Alzheimer’s disease. [(18)F]PF-06684511 is a positron emission tomography (PET) radioligand for imaging BACE1. Despite favorable brain kinetic properties, the effective dose (ED) of [(18)F]PF-06684511 estimated in non-h...

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Udgivet i:Eur J Nucl Med Mol Imaging
Main Authors: Arakawa, Ryosuke, Takano, Akihiro, Stenkrona, Per, Stepanov, Vladimir, Nag, Sangram, Jahan, Mahabuba, Grybäck, Per, Bolin, Martin, Chen, Laigao, Zhang, Lei, He, Ping, Villalobos, Anabella, McCarthy, Timothy J., Halldin, Christer, Varrone, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396399/
https://ncbi.nlm.nih.gov/pubmed/32140803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-020-04739-5
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