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Bioorthogonal Click Chemistries Enable Simultaneous Spatial Patterning of Multiple Proteins to Probe Synergistic Protein Effects on Fibroblast Function

Three biorthogonal click reactions, a photoinitiated thiol-yne reaction, an azide-alkyne cycloaddition, and a methyltetrazine-transcyclooctene Diels Alder, were used to independently control the presentation of several bioactive proteins to valvular interstitial cells (VICs) in hydrogel scaffolds. T...

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發表在:Biomaterials
Main Authors: Ma, Hao, Caldwell, Alexander S., Azagarsamy, Malar A., Rodriguez, Andrea Gonzalez, Anseth, Kristi S.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396286/
https://ncbi.nlm.nih.gov/pubmed/32574845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2020.120205
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