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Nonclinical Pharmacokinetic and Pharmacodynamic Assessment of Bimatoprost Following a Single Intracameral Injection of Sustained-Release Implants
PURPOSE: To assess the pharmacokinetic (PK)/pharmacodynamic (PD) relationship following intracameral Bimatoprost sustained-release (SR) implants (8, 15, 30, and 60 µg) in dogs to determine the optimal investigative dose in humans. METHODS: Forty-four male normotensive beagle dogs were assigned to 1...
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| 發表在: | Transl Vis Sci Technol |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The Association for Research in Vision and Ophthalmology
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7396179/ https://ncbi.nlm.nih.gov/pubmed/32818107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.9.4.20 |
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