Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

Chronic inflammation is a key pathological hallmark of multiple sclerosis (MS) and suggests that resolution of inflammation, orchestrated by specialized pro-resolving lipid mediators (LM), is impaired. Here, through targeted-metabololipidomics in peripheral blood of patients with MS, we revealed tha...

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Pubblicato in:Haematologica
Autori principali: Kooij, Gijs, Troletti, Claudio Derada, Leuti, Alessandro, Norris, Paul C., Riley, Ian, Albanese, Maria, Ruggieri, Serena, Libreros, Stephania, van der Pol, Susanne M.A., van het Hof, Bert, Schell, Yoelle, Guerrera, Gisella, Buttari, Fabio, Mercuri, Nicola Biagio, Centonze, Diego, Gasperini, Claudio, Battistini, Luca, de Vries, Helga E., Serhan, Charles N., Chiurchiù, Valerio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Fondazione Ferrata Storti 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395264/
https://ncbi.nlm.nih.gov/pubmed/31780628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.219519
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