Activation of Protein Kinase A (PKA) signaling mitigates congenital hyperinsulinism associated hypoglycemia in the Sur1(-/-) mouse model

There is a significant unmet need for a safe and effective therapy for the treatment of children with congenital hyperinsulinism. We hypothesized that amplification of the glucagon signaling pathway could ameliorate hyperinsulinism associated hypoglycemia. In order to test this we evaluated the effe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Soundarapandian, Mangala M., Juliana, Christine A., Chai, Jinghua, Haslett, Patrick A., Fitzgerald, Kevin, De León, Diva D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394442/
https://ncbi.nlm.nih.gov/pubmed/32735622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0236892
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