Hydroxychloroquine to Prevent Recurrent Congenital Heart Block in Fetuses of Anti-SSA/Ro-Positive Mothers

BACKGROUND: Experimental and clinical evidence slupport the role of macrophage Toll-like receptor (TLR) signaling in maternal anti-SSA/Ro-mediated congenital heart block (CHB). OBJECTIVES: Hydroxychloroquine (HCQ), an orally administered TLR antagonist widely used in lupus including during pregnancy...

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Publié dans:J Am Coll Cardiol
Auteurs principaux: Izmirly, Peter, Kim, Mimi, Friedman, Deborah M., Costedoat-Chalumeau, Nathalie, Clancy, Robert, Copel, Joshua A., Phoon, Colin K. L., Cuneo, Bettina F., Cohen, Rebecca, Robins, Kimberly, Masson, Mala, Wainwright, Benjamin J., Zahr, Noel, Saxena, Amit, Buyon, Jill P.
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394202/
https://ncbi.nlm.nih.gov/pubmed/32674792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2020.05.045
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