Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

BACKGROUND: Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However, whether and how the nature of the CNS insult—acute versus chronic—influences the astrocyte response, and whether astrocyte tra...

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Udgivet i:J Neuroinflammation
Main Authors: Das, Sudeshna, Li, Zhaozhi, Noori, Ayush, Hyman, Bradley T., Serrano-Pozo, Alberto
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393869/
https://ncbi.nlm.nih.gov/pubmed/32736565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01898-y
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