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Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Neurodegenerative disorders such as Alzheimer’s disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum are defined by the accumulation of specific misfolded protein aggregates. However, the mechanisms by which each proteinopathy l...

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Bibliografiska uppgifter
I publikationen:Neurobiol Dis
Huvudupphovsmän: Noori, Ayush, Mezlini, Aziz M., Hyman, Bradley T., Serrano-Pozo, Alberto, Das, Sudeshna
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856076/
https://ncbi.nlm.nih.gov/pubmed/33347974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105225
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