New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses

BACKGROUND: PRR (Pattern Recognition Receptor) agonists have been widely tested as potent vaccine adjuvants. TLR7 (Toll-Like Receptor 7) and NOD2 (nucleotide-binding oligomerization domain 2) are key innate receptors widely expressed at mucosal levels. METHODS: Here, we evaluated the immunostimulato...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Gutjahr, Alice, Papagno, Laura, Vernejoul, Fabienne, Lioux, Thierry, Jospin, Fabienne, Chanut, Blandine, Perouzel, Eric, Rochereau, Nicolas, Appay, Victor, Verrier, Bernard, Paul, Stéphane
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393532/
https://ncbi.nlm.nih.gov/pubmed/32739871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102922
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