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TP53 mutational landscape of metastatic head and neck cancer reveals patterns of mutation selection

BACKGROUND: Head and neck squamous cell carcinoma is a heterogeneous disease with respect to the anatomic site of the primary tumor. On the other hand, it is highly recurrent, and once metastatic, it is associated with poor prognosis. TP53 is the most commonly mutated gene in primary disease. TP53 m...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Klinakis, Apostolos, Rampias, Theodoros
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393519/
https://ncbi.nlm.nih.gov/pubmed/32739866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102905
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