Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis

The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of...

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Dettagli Bibliografici
Pubblicato in:JACC Basic Transl Sci
Autori principali: Perrot, Nicolas, Valerio, Vincenza, Moschetta, Donato, Boekholdt, S. Matthijs, Dina, Christian, Chen, Hao Yu, Abner, Erik, Martinsson, Andreas, Manikpurage, Hasanga D., Rigade, Sidwell, Capoulade, Romain, Mass, Elvira, Clavel, Marie-Annick, Le Tourneau, Thierry, Messika-Zeitoun, David, Wareham, Nicholas J., Engert, James C., Polvani, Gianluca, Pibarot, Philippe, Esko, Tõnu, Smith, J. Gustav, Mathieu, Patrick, Thanassoulis, George, Schott, Jean-Jacques, Bossé, Yohan, Camera, Marina, Thériault, Sébastien, Poggio, Paolo, Arsenault, Benoit J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
CLINICAL RESEARCH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393433/
https://ncbi.nlm.nih.gov/pubmed/32760854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.05.004
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