De novo protein design enables precise induction of RSV neutralizing antibodies

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remains a cornerstone for next-generation vaccines...

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Publié dans:Science
Auteurs principaux: Sesterhenn, Fabian, Yang, Che, Bonet, Jaume, Cramer, Johannes T, Wen, Xiaolin, Wang, Yimeng, Chiang, Chi-I, Abriata, Luciano A, Kucharska, Iga, Castoro, Giacomo, Vollers, Sabrina S, Galloux, Marie, Dheilly, Elie, Rosset, Stéphane, Corthésy, Patricia, Georgeon, Sandrine, Villard, Mélanie, Richard, Charles-Adrien, Descamps, Delphyne, Delgado, Teresa, Oricchio, Elisa, Rameix-Welti, Marie-Anne, Más, Vicente, Ervin, Sean, Eléouët, Jean-François, Riffault, Sabine, Bates, John T, Julien, Jean-Philippe, Li, Yuxing, Jardetzky, Theodore, Krey, Thomas, Correia, Bruno E
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391827/
https://ncbi.nlm.nih.gov/pubmed/32409444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay5051
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