Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias

Hypospadias is a common birth defect where the urethral opening forms on the ventral side of the penis. We performed integrative methylomic, genomic, and transcriptomic analyses to characterize sites of DNA methylation that influence genital development. In case–control and case-only epigenome-wide...

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Vydáno v:Sci Rep
Hlavní autoři: Richard, Melissa A., Sok, Pagna, Canon, Stephen, Nembhard, Wendy N., Brown, Austin L., Peckham-Gregory, Erin C., Ton, Minh, Ehli, Erik A., Kallsen, Noah A., Peyton, Shanna A., Davies, Gareth E., Patel, Ashay, Zamilpa, Ismael, Hobbs, Charlotte A., Scheurer, Michael E., Lupo, Philip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391634/
https://ncbi.nlm.nih.gov/pubmed/32728162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-69725-1
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