Large-scale GMP-compliant CRISPR-Cas9–mediated deletion of the glucocorticoid receptor in multivirus-specific T cells

Virus-specific T cells have proven highly effective for the treatment of severe and drug-refractory infections after hematopoietic stem cell transplant (HSCT). However, the efficacy of these cells is hindered by the use of glucocorticoids, often given to patients for the management of complications...

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Foilsithe in:Blood Adv
Main Authors: Basar, Rafet, Daher, May, Uprety, Nadima, Gokdemir, Elif, Alsuliman, Abdullah, Ensley, Emily, Ozcan, Gonca, Mendt, Mayela, Hernandez Sanabria, Mayra, Kerbauy, Lucila Nassif, Nunez Cortes, Ana Karen, Li, Li, Banerjee, Pinaki P., Muniz-Feliciano, Luis, Acharya, Sunil, Fowlkes, Natalie W., Lu, Junjun, Li, Sufang, Mielke, Stephan, Kaplan, Mecit, Nandivada, Vandana, Bdaiwi, Mustafa, Kontoyiannis, Alexander D., Li, Ye, Liu, Enli, Ang, Sonny, Marin, David, Brunetti, Lorenzo, Gundry, Michael C., Turk, Rolf, Schubert, Mollie S., Rettig, Garrett R., McNeill, Matthew S., Kurgan, Gavin, Behlke, Mark A., Champlin, Richard, Shpall, Elizabeth J., Rezvani, Katayoun
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2020
Ábhair:
Transplantation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7391161/
https://ncbi.nlm.nih.gov/pubmed/32717029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001977
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