Quantification of neutralizing anti-drug antibodies and their neutralizing capacity using competitive displacement and tandem mass spectrometry: Infliximab as proof of principle

BACKGROUND: The development of anti-drug antibodies (ADA) in patients treated with therapeutic proteins can result in treatment failure. The clinically most relevant fraction of these antibodies are the neutralizing anti-drug antibodies (NAb) that block the pharmacological function of the drug. Cons...

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Udgivet i:J Transl Autoimmun
Main Authors: El Amrani, Mohsin, Göbel, Camiel, Egas, Annelies C., Nierkens, Stefan, Hack, C. Erik, Huitema, Alwin D.R., van Maarseveen, Erik M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388346/
https://ncbi.nlm.nih.gov/pubmed/32743494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtauto.2019.100004
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