A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment-Resistant Depression

BACKGROUND: Ketamine has rapid-acting antidepressant effects but is associated with psychotomimetic and other adverse effects. A 7-chlorokynurenic acid is a potent and specific glycine site N-methyl-d-aspartate receptor antagonist but crosses the blood-brain barrier inefficiently. Its prodrug, L-4-c...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Park, Lawrence T, Kadriu, Bashkim, Gould, Todd D, Zanos, Panos, Greenstein, Deanna, Evans, Jennifer W, Yuan, Peixiong, Farmer, Cristan A, Oppenheimer, Mark, George, Jomy M, Adeojo, Lilian W, Snodgrass, H Ralph, Smith, Mark A, Henter, Ioline D, Machado-Vieira, Rodrigo, Mannes, Andrew J, Zarate, Carlos A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Regular Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387765/
https://ncbi.nlm.nih.gov/pubmed/32236521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyaa025
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