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Gain of chromosome 21 in hematological malignancies: lessons from studying leukemia in children with Down syndrome

Structural and numerical alterations of chromosome 21 are extremely common in hematological malignancies. While the functional impact of chimeric transcripts from fused chromosome 21 genes such as TEL-AML1, AML1-ETO, or FUS-ERG have been extensively studied, the role of gain of chromosome 21 remains...

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Publicado en:Leukemia
Autores principales: Laurent, Anouchka P., Kotecha, Rishi S., Malinge, Sébastien
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387246/
https://ncbi.nlm.nih.gov/pubmed/32433508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-020-0854-5
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