TERT, BRAF, and NRAS mutational heterogeneity between paired primary and metastatic melanoma tumors

Mutational heterogeneity can contribute to therapeutic resistance in solid cancers. In melanoma, the frequency of inter- and intra-tumoral heterogeneity is controversial. We examined mutational heterogeneity within individual melanoma patients using multi-platform analysis of commonly mutated driver...

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Pubblicato in:J Invest Dermatol
Autori principali: Chang, Gregory A., Wiggins, Jennifer M., Corless, Broderick C., Syeda, Mahrukh M., Tadepalli, Jyothirmayee S., Blake, Shria, Fleming, Nathaniel, Darvishian, Farbod, Pavlick, Anna, Berman, Russell, Shapiro, Richard, Shao, Yongzhao, Karlin-Neumann, George, Spittle, Cindy, Osman, Iman, Polsky, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7387168/
https://ncbi.nlm.nih.gov/pubmed/32087194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.01.027
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