Intra- and Inter-Tumor Heterogeneity of BRAF(V600E)Mutations in Primary and Metastatic Melanoma

The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With the emergence of BRAF(V600E) as a therapeutic target, we investigated intra- and...

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Detalhes bibliográficos
Main Authors: Yancovitz, Molly, Litterman, Adam, Yoon, Joanne, Ng, Elise, Shapiro, Richard L., Berman, Russell S., Pavlick, Anna C., Darvishian, Farbod, Christos, Paul, Mazumdar, Madhu, Osman, Iman, Polsky, David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250426/
https://ncbi.nlm.nih.gov/pubmed/22235286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029336
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