Intra- and Inter-Tumor Heterogeneity of BRAF(V600E)Mutations in Primary and Metastatic Melanoma

The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With the emergence of BRAF(V600E) as a therapeutic target, we investigated intra- and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Yancovitz, Molly, Litterman, Adam, Yoon, Joanne, Ng, Elise, Shapiro, Richard L., Berman, Russell S., Pavlick, Anna C., Darvishian, Farbod, Christos, Paul, Mazumdar, Madhu, Osman, Iman, Polsky, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2012
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250426/
https://ncbi.nlm.nih.gov/pubmed/22235286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029336
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