Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell

Dosage suppression is a genetic interaction in which overproduction of one gene rescues a mutant phenotype of another gene. Although dosage suppression is known to map functional connections among genes, the extent to which It might illuminate global cellular functions is unclear. Here we analyze a...

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Veröffentlicht in:Nat Biotechnol
Hauptverfasser: Magtanong, Leslie, Ho, Cheuk Hei, Barker, Sarah L, Jiao, Wei, Baryshnikova, Anastasia, Bahr, Sondra, Smith, Andrew M, Heisler, Lawrence E, Choy, John S, Kuzmin, Elena, Andrusiak, Kerry, Kobylianski, Anna, Li, Zhijian, Costanzo, Michael, Basrai, Munira A, Giaever, Guri, Nislow, Corey, Andrewa, Brenda, Boone, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386433/
https://ncbi.nlm.nih.gov/pubmed/21572441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1855
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