Subtle Changes in Surface-tethered Groups on PEGylated DNA Nanoparticles Significantly Influence Gene Transfection and Cellular Uptake

PEGylation strategy has been widely used to enhance colloidal stability of polycation/DNA nanoparticles (NPs) for gene delivery. To investigate the effect of polyethylene glycol (PEG) terminal groups on the transfection properties of these NPs, we synthesized DNA NPs using PEG-g-linear polyethylenei...

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Gepubliceerd in:Nanomedicine
Hoofdauteurs: Ke, Xiyu, Wei, Zonghui, Wang, Ying, Shen, Sabrina, Ren, Yong, Williford, John-Michael, Luijten, Erik, Mao, Hai-Quan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386071/
https://ncbi.nlm.nih.gov/pubmed/31048082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2019.04.004
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