Mithramycin selectively attenuates DNA-damage-induced neuronal cell death

DNA damage triggers cell death mechanisms contributing to neuronal loss and cognitive decline in neurological disorders, including traumatic brain injury (TBI), and as a side effect of chemotherapy. Mithramycin, which competitively targets chromatin-binding sites of specificity protein 1 (Sp1), was...

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Pubblicato in:Cell Death Dis
Autori principali: Makarevich, Oleg, Sabirzhanov, Boris, Aubrecht, Taryn G., Glaser, Ethan P., Polster, Brian M., Henry, Rebecca J., Faden, Alan I., Stoica, Bogdan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385624/
https://ncbi.nlm.nih.gov/pubmed/32719328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02774-6
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