Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury

Traumatic brain injury (TBI) activates multiple neuronal cell death mechanisms, leading to post-traumatic neuronal loss and neurological deficits. TBI-induced cell cycle activation (CCA) in post-mitotic neurons causes regulated cell death involving cyclin-dependent kinase (CDK) activation and initia...

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Pubblicato in:Cell Death Dis
Autori principali: Aubrecht, Taryn G., Faden, Alan I., Sabirzhanov, Boris, Glaser, Ethan P., Roelofs, Brian A., Polster, Brian M., Makarevich, Oleg, Stoica, Bogdan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219504/
https://ncbi.nlm.nih.gov/pubmed/30401820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1156-y
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