Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly

AIMS/HYPOTHESIS: Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly. METHODS: We selected controls from ADNI2 with CSF AD biomarkers and/or...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement (Amst)
Main Authors: Pegueroles, Jordi, Pané, Adriana, Vilaplana, Eduard, Montal, Víctor, Bejanin, Alexandre, Videla, Laura, Carmona‐Iragui, María, Barroeta, Isabel, Ibarzabal, Ainitze, Casajoana, Anna, Alcolea, Daniel, Valldeneu, Silvia, Altuna, Miren, de Hollanda, Ana, Vidal, Josep, Ortega, Emilio, Osorio, Ricardo, Convit, Antonio, Blesa, Rafael, Lleó, Alberto, Fortea, Juan, Jiménez, Amanda
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Diagnostic Assessment & Prognosis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385480/
https://ncbi.nlm.nih.gov/pubmed/32743041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dad2.12052
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