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Glycogen synthase kinase‐3 inhibition overcomes epithelial‐mesenchymal transition‐associated resistance to osimertinib in EGFR‐mutant lung cancer

A novel epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor, osimertinib, has marked efficacy in patients with EGFR‐mutant lung cancer. While epithelial‐mesenchymal transition (EMT) plays a role in the resistance to various targeted drugs, its involvement in EGFR‐inhibitor resistance r...

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Foilsithe in:Cancer Sci
Main Authors: Fukuda, Koji, Takeuchi, Shinji, Arai, Sachiko, Kita, Kenji, Tanimoto, Azusa, Nishiyama, Akihiro, Yano, Seiji
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385349/
https://ncbi.nlm.nih.gov/pubmed/32391602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14454
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