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Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
Reactive astrocytes have been implicated in the pathogenesis of neurodegenerative diseases, including a non-cell autonomous effect on motor neuron survival in ALS. We previously defined a mechanism by which microglia release three factors, IL-1α, TNFα, and C1q, to induce neurotoxic astrocytes. Here...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7385161/ https://ncbi.nlm.nih.gov/pubmed/32719333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17514-9 |
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