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Effect of the Substrate Structure and Metal Ions on the Hydrolysis of Undamaged RNA by Human AP Endonuclease APE1

Human apurinic/apyrimidinic (AP) endonuclease APE1 is one of the participants in the DNA base excision repair. The main biological function of APE1 is to hydrolyze the phosphodiester bond on the 5′-side of the AP sites. It has been shown recently that APE1 acts as an endoribonuclease and can cleave...

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Библиографические подробности
Опубликовано в: :Acta Naturae
Главные авторы: Kuznetsova, A. A., Novopashina, D. S., Fedorova, O. S., Kuznetsov, N. A.
Формат: Artigo
Язык:Inglês
Опубликовано: A.I. Gordeyev 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385091/
https://ncbi.nlm.nih.gov/pubmed/32742730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.32607/actanaturae.10864
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