Maternal Pregravid Obesity Remodels the DNA Methylation Landscape of Cord Blood Monocytes Disrupting its Inflammatory Program

Pre-pregnancy maternal obesity is associated with adverse outcomes for the offspring, including increased incidence of neonatal bacterial sepsis and necrotizing enterocolitis. We recently reported that umbilical cord blood (UCB) monocytes from babies born to obese mothers generate a reduced IL6/TNFα...

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Pubblicato in:J Immunol
Autori principali: Sureshchandra, Suhas, Wilson, Randall M., Rais, Maham, Marshall, Nicole E., Purnell, Jonathan Q., Thornburg, Kent L., Messaoudi, Ilhem
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384891/
https://ncbi.nlm.nih.gov/pubmed/28887432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700434
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