Activation of PGK1 under hypoxic conditions promotes glycolysis and increases stem cell-like properties and the epithelial-mesenchymal transition in oral squamous cell carcinoma cells via the AKT signalling pathway

Although it has been previously documented that a hypoxic environment can promote glycolysis and the malignant progression of oral squamous cell carcinoma (OSCC) cells, the specific underlying mechanism remains unclear. Phosphoglycerate kinase 1 (PGK1) has been previously reported to serve an import...

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Publicat a:Int J Oncol
Autors principals: Zhang, Yadong, Cai, Hongshi, Liao, Yan, Zhu, Yue, Wang, Fang, Hou, Jinsong
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384853/
https://ncbi.nlm.nih.gov/pubmed/32705252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2020.5083
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