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Fecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice

OBJECTIVES: Emerging evidence suggests the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one ‘hit’ is provided by an adverse gut microbiome that activates innate immunity; the other ‘hit’...

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Bibliografske podrobnosti
izdano v:Ann Rheum Dis
Main Authors: Huang, ZeYu, Chen, Jing, Li, BoLei, Zeng, Benhua, Chou, Ching-Heng, Zheng, Xin, Xie, JingWei, Li, Hao, Hao, Yu, Chen, Guo, Pei, FuXing, Shen, Bin, Kraus, Virginia Byers, Wei, Hong, Zhou, XueDong, Cheng, Lei
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384301/
https://ncbi.nlm.nih.gov/pubmed/32205337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-216471
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