Metabolic co-essentiality mapping identifies c12orf49 as a regulator of SREBP processing and cholesterol metabolism

Co-essentiality mapping has been useful to systematically cluster genes into biological pathways and identify gene functions1(–)3. Here, using the debiased sparse partial correlation (DSPC) method3, we construct a functional co-essentiality map for cellular metabolic processes across human cancer ce...

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Pubblicato in:Nat Metab
Autori principali: Bayraktar, Erol C., La, Konnor, Karpman, Kara, Unlu, Gokhan, Ozerdem, Ceren, Ritter, Dylan J., Alwaseem, Hanan, Molina, Henrik, Hoffmann, Hans-Heinrich, Millner, Alec, Atilla-Gokcumen, G. Ekin, Gamazon, Eric R., Rushing, Amy R., Knapik, Ela W., Basu, Sumanta, Birsoy, Kıvanç
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384252/
https://ncbi.nlm.nih.gov/pubmed/32694732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-0206-9
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