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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to conventional small molecule inhibitors (SMIs) because of their unique mechanism of action (MOA...
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| Veröffentlicht in: | J Hematol Oncol |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7384229/ https://ncbi.nlm.nih.gov/pubmed/32718354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-00924-z |
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