Synthesis, Radiosynthesis and Biological Evaluation of Buprenorphine‐Derived Phenylazocarboxamides as Novel μ‐Opioid Receptor Ligands

Targeted structural modifications have led to a novel type of buprenorphine‐derived opioid receptor ligand displaying an improved selectivity profile for the μ‐OR subtype. On this basis, it is shown that phenylazocarboxamides may serve as useful bioisosteric replacements for the widely occurring cin...

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Bibliografiske detaljer
Udgivet i:ChemMedChem
Main Authors: Krüll, Jasmin, Fehler, Stefanie K., Hofmann, Laura, Nebel, Natascha, Maschauer, Simone, Prante, Olaf, Gmeiner, Peter, Lanig, Harald, Hübner, Harald, Heinrich, Markus R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Full Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383964/
https://ncbi.nlm.nih.gov/pubmed/32378310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000180
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