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The Evolutionarily Conserved piRNA-producing Locus pi6 Is Required for Male Mouse Fertility

Pachytene piRNAs, which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target RNAs like miRNAs, cleave targets like siRNAs, or lack biological function altogether. Although piRNA pathway protein mutants are male sterile, no biological function has b...

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Vydáno v:Nat Genet
Hlavní autoři: Wu, Pei-Hsuan, Fu, Yu, Cecchini, Katharine, Özata, Deniz M., Arif, Amena, Yu, Tianxiong, Colpan, Cansu, Gainetdinov, Ildar, Weng, Zhiping, Zamore, Phillip D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383350/
https://ncbi.nlm.nih.gov/pubmed/32601478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0657-7
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