Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

Tight-junction-regulated actomyosin activity determines epithelial and endothelial tension on adherens junctions and drives morphogenetic processes; however, whether or not tight junctions themselves are under tensile stress is not clear. Here, we use a tension sensor based on ZO-1, a scaffolding pr...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Haas, Alexis J., Zihni, Ceniz, Ruppel, Artur, Hartmann, Christian, Ebnet, Klaus, Tada, Masazumi, Balda, Maria S., Matter, Karl
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383227/
https://ncbi.nlm.nih.gov/pubmed/32697990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107924
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