Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity

BACKGROUND: Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover mutations that confer phenotypic functions of interest. However, the task of finding and understanding all beneficial mutations of an ALE experiment remains an open challenge for the field. To provide...

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Bibliographic Details
Published in:BMC Genomics
Main Authors: Phaneuf, Patrick V., Yurkovich, James T., Heckmann, David, Wu, Muyao, Sandberg, Troy E., King, Zachary A., Tan, Justin, Palsson, Bernhard O., Feist, Adam M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382830/
https://ncbi.nlm.nih.gov/pubmed/32711472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-06920-4
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