Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity

BACKGROUND: Adaptive Laboratory Evolution (ALE) has emerged as an experimental approach to discover mutations that confer phenotypic functions of interest. However, the task of finding and understanding all beneficial mutations of an ALE experiment remains an open challenge for the field. To provide...

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Vydáno v:BMC Genomics
Hlavní autoři: Phaneuf, Patrick V., Yurkovich, James T., Heckmann, David, Wu, Muyao, Sandberg, Troy E., King, Zachary A., Tan, Justin, Palsson, Bernhard O., Feist, Adam M.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Methodology Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382830/
https://ncbi.nlm.nih.gov/pubmed/32711472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-06920-4
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