Evidence for GTKO/β4GalNT2KO Pigs as the Preferred Organ-source for Old World Nonhuman Primates as a Preclinical Model of Xenotransplantation

BACKGROUND. Triple-knockout (TKO) pigs (in which expression of the 3 known pig carbohydrate xenoantigens has been deleted) are likely to be an optimal source of organs for transplantation into human recipients, many of whom do not have natural antibodies against TKO pig cells. However, old world mon...

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Опубликовано в: :Transplant Direct
Главные авторы: Cui, Yehua, Yamamoto, Takayuki, Raza, Syed Sikandar, Morsi, Mahmoud, Nguyen, Huy Quoc, Ayares, David, Cooper, David K.C., Hara, Hidetaka
Формат: Artigo
Язык:Inglês
Опубликовано: Lippincott Williams & Wilkins 2020
Предметы:
Xenotransplantation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382549/
https://ncbi.nlm.nih.gov/pubmed/32766438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000001038
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